Discovery and in vitro and in vivo profiles of 4-fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide as novel class of an orally active metabotropic glutamate receptor 1 (mGluR1) antagonist-Reference-Cited by-同舟云学术

Discovery and in vitro and in vivo profiles of 4-fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide as novel class of an orally active metabotropic glutamate receptor 1 (mGluR1) antagonist

Published:2009-09 Issue:18 Volume:19 Page:5464-5468
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Satoh Atsushi,Nagatomi Yasushi,Hirata Yukari,Ito Satoru,Suzuki Gentaroh,Kimura Toshifumi,Maehara Shunsuke,Hikichi Hirohiko,Satow Akio,Hata Mikiko,Ohta Hisashi,Kawamoto Hiroshi

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference20 articles.

1. Positive and negative allosteric modulation of metabotropic glutamate receptors: emerging therapeutic potential

2. Glutamate-based therapeutic approaches: allosteric modulators of metabotropic glutamate receptors

3. Metabotropic glutamate receptors as novel targets for anxiety and stress disorders

4. Glutamate and Schizophrenia: Pathophysiology and Therapeutics

5. A novel class of antagonists for metabotropic glutamate receptors, 7-(Hydroxyimino)cyclopropa[b]chromen-1a-carboxylates

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