Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: Structure based design and in vivo reduction of amyloid β-peptides-Reference-Cited by-同舟云学术

Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: Structure based design and in vivo reduction of amyloid β-peptides

Published:2013-10 Issue:19 Volume:23 Page:5300-5306
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Rueeger Heinrich,Lueoend Rainer,Machauer Rainer,Veenstra Siem Jacob,Jacobson Laura Helen,Staufenbiel Matthias,Desrayaud Sandrine,Rondeau Jean-Michel,Möbitz Henrik,Neumann Ulf

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference35 articles.

1. Alzheimer's disease: strategies for disease modification

2. Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

3. Human aspartic protease memapsin 2 cleaves the beta -secretase site of beta -amyloid precursor protein

4. Purification and cloning of amyloid precursor protein β-secretase from human brain

5. β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

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