Synthesis and evaluation of 8,4′-dideshydroxy-leinamycin revealing new insights into the structure–activity relationship of the anticancer natural product leinamycin-Reference-Cited by-同舟云学术

Synthesis and evaluation of 8,4′-dideshydroxy-leinamycin revealing new insights into the structure–activity relationship of the anticancer natural product leinamycin

Published:2015-11 Issue:21 Volume:25 Page:4899-4902
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Liu Tao,Ma Ming,Ge Hui-Ming,Yang Chunying,Cleveland John,Shen Ben

Funder

National Institutes of Health

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference28 articles.

1. DC 107, a novel antitumor antibiotic produced by a Streptomyces sp.

2. DNA strand scission by the novel antitumor antibiotic leinamycin

3. Antitumor activity of KF22678, a novel thioester derivative of leinamycin

4. Mechanisms of DNA Damage by Leinamycin

5. Thiol-Mediated DNA Alkylation by the Novel Antitumor Antibiotic Leinamycin

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