Discovery of aminoheterocycles as a novel β-secretase inhibitor class: pH dependence on binding activity part 1-Reference-Cited by-同舟云学术

Discovery of aminoheterocycles as a novel β-secretase inhibitor class: pH dependence on binding activity part 1

Published:2009-06 Issue:11 Volume:19 Page:2977-2980
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Stachel Shawn J.,Coburn Craig A.,Rush Diane,Jones Kristen L.G.,Zhu Hong,Rajapakse Hemaka,Graham Samuel L.,Simon Adam,Katharine Holloway M.,Allison Tim J.,Munshi Sanjeev K.,Espeseth Amy S.,Zuck Paul,Colussi Dennis,Wolfe Abigail,Pietrak Beth L.,Lai Ming-Tain,Vacca Joseph P.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference22 articles.

1. The Role of Amyloid-Beta Derived Diffusible Ligands (ADDLs) in Alzheimers Disease

2. Purification and cloning of amyloid precursor protein β-secretase from human brain

3. Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity

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