The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA α5 inverse agonists for the treatment of cognitive dysfunction-Reference-Cited by-同舟云学术

The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA α5 inverse agonists for the treatment of cognitive dysfunction

Published:2009-10 Issue:20 Volume:19 Page:5940-5944
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Knust Henner,Achermann Guido,Ballard Theresa,Buettelmann Bernd,Gasser Rodolfo,Fischer Holger,Hernandez Maria-Clemencia,Knoflach Frédéric,Koblet Andreas,Stadler Heinz,Thomas Andrew W.,Trube Gerhard,Waldmeier Pius

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference21 articles.

1. Pharmacology of the benzodiazepine receptor

2. An Inverse Agonist Selective for α5 Subunit-Containing GABAA Receptors Enhances Cognition

3. GABAA Receptor Subtype Selective Cognition Enhancers

4. The GABA A receptor as a potential target for the treatment of cognitive dysfunction

5. GABAAreceptors in aging and Alzheimer’s disease

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