Synthesis and biological evaluation of novel hexahydro-pyrido[3′,2′:4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT2C receptor agonists-Reference-Cited by-同舟云学术

Synthesis and biological evaluation of novel hexahydro-pyrido[3′,2′:4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT2C receptor agonists

Published:2006-03 Issue:5 Volume:16 Page:1207-1211
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Richter Hans G.F.,Adams D.R.,Benardeau A.,Bickerdike M.J.,Bentley J.M.,Blench T.J.,Cliffe I.A.,Dourish C.,Hebeisen P.,Kennett G.A.,Knight A.R.,Malcolm C.S.,Mattei P.,Misra A.,Mizrahi J.,Monck N.J.T.,Plancher J.-M.,Roever S.,Roffey J.R.A.,Taylor S.,Vickers S.P.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference16 articles.

1. Current Concepts in the Pharmacological Management of Obesity

2. 5-HT2C receptor modulation and the treatment of obesity

3. Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors

4. SB 242084, a Selective and Brain Penetrant 5-HT 2C Receptor Antagonist

5. 5-HT 2C receptor activation decreases appetite and body weight in obese subjects

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