Pyridone-Containing farnesyltransferase inhibitors: synthesis and biological evaluation

Author:

Hasvold Lisa A.,Wang Weibo,Gwaltney, Stephen L.,Rockway Todd W.,Nelson Lissa T.J.,Mantei Robert A.,Fakhoury Stephen A.,Sullivan Gerard M.,Li Qun,Lin Nan-Horng,Wang Le,Zhang Haiying,Cohen Jerome,Gu Wen-Zhen,Marsh Kennan,Bauch Joy,Rosenberg Saul,Sham Hing L.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference7 articles.

1. Farnesyltransferase inhibitors: mechanism and applications

2. Farnesyltransferase inhibitors: antineoplastic mechanism and clinical prospects

3. Wang, W.; Curtin, M. L.; Fakhoury, S. A.; Gwaltney, S. L., II; Hasvold, L. A.; Hutchins, C. W.; Li, Q.; Lin, N.; Nelson, L. T. J.; O'Connor, S. J.; Sham, H. L.; Sullivan, G. M.; Wang, G. T.; Wang, X. World Patent WO 01/81316; Chem Abstr. 2001, 135, 344482.

4. A Non-peptide Mimetic of Ras-CAAX: Selective Inhibition of Farnesyltransferase and Ras Processing

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