Imidazopyridazinones as novel PDE7 inhibitors: SAR and in vivo studies in Parkinson’s disease model-Reference-Cited by-同舟云学术

Imidazopyridazinones as novel PDE7 inhibitors: SAR and in vivo studies in Parkinson’s disease model

Published:2012-10 Issue:19 Volume:22 Page:6286-6291
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Banerjee Abhisek,Patil Sandip,Pawar Mahesh Y.,Gullapalli Srinivas,Gupta Praveen K.,Gandhi Maulik N.,Bhateja Deepak K.,Bajpai Malini,Sangana Ramachandra Rao,Gudi Girish S.,Khairatkar-Joshi Neelima,Gharat Laxmikant A.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference23 articles.

1. Phosphodiesterase 7 (PDE7) as a therapeutic target

2. Neuroinflammatory mechanisms in Parkinson's disease: Potential environmental triggers, pathways, and targets for early therapeutic intervention

3. The Role of Anti-Inflammatory Agents in Parkinson???s Disease

4. Phosphodiesterase 7 Inhibition Preserves Dopaminergic Neurons in Cellular and Rodent Models of Parkinson Disease

5. The role of PDE7 inhibitors to enhancing neuroprotection in wellcharacterized cellular and animal models of spinal cord injury, stroke and multiple sclerosis is demonstrated in the following references, respectively. (a) Paterniti, I.; Mazzon, E.; Gil, C.; Impllizzari, D.; Palomo, V.; Redondo, M.; Perez, D. I.; Esposito, E.; Martinez, A.; Cuzzocrea, S. PLoS ONE 2011, 6, e15937; (b) Redondo, M.; Zarruk, J. G.; Ceballos, P.; Pérez, D. I.; Pérez, C.; Perez-Castillo, A.; Moro, M. A.; Brea, J.; Val, C.; Cadavid, M. I.; Loza, M. I.; Campillo, N. E.; Martínez, A.; Gil, C. Eur. J. Med. Chem. 2012, 47, 175; (c) Redondo, M.; Brea, J.; Perez, D. I.; Soteras, I.; Val, C.; Perez, C.; Morales-García, J. A.; Alonso-Gil, S.; Paul-Fernandez, N.; Martin-Alvarez, R.; Cadavid, M. I.; Loza, M. I.; Perez-Castillo, A.; Mengod, G.; Campillo, N. E.; Martinez, A.; Gil, C. J. Med. Chem. 2012, 55, 3274.

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