Synthesis and SAR of GlyT1 inhibitors derived from a series of N-((4-(morpholine-4-carbonyl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamides-Reference-Cited by-同舟云学术

Synthesis and SAR of GlyT1 inhibitors derived from a series of N-((4-(morpholine-4-carbonyl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamides

Published:2006-12 Issue:23 Volume:16 Page:5968-5972
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Zhao Zhijian,O’Brien Julie A.,Lemaire Wei,Williams David L.,Jacobson Marlene A.,Sur Cyrille,Pettibone Doug J.,Tiller Philip R.,Smith Sheri,Hartman George D.,Wolkenberg Scott E.,Lindsley Craig W.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

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4. Direct and Indirect Modulation of the N-Methyl D-Aspartate Receptor: Potential for the Development of Novel Antipsychotic Therapies

5. Effect of Chlorpromazine or Haloperidol on Formation of 3-Methoxytyramine and Normetanephrine in Mouse Brain

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1. Discovery of 3-Chloro-N-{(S)-[3-(1-ethyl-1H-pyrazol-4-yl)phenyl][(2S)-piperidine-2-yl]methyl}-4-(trifluoromethyl)pyridine-2-carboxamide as a Potent Glycine Transporter 1 Inhibitor;Chemical and Pharmaceutical Bulletin;2016

2. GlyT-1 Inhibitors: From Hits to Clinical Candidates;Small Molecule Therapeutics for Schizophrenia;2014

3. Case Study 1: Scaffold Hopping for T‐Type Calcium Channel and Glycine Transporter Type 1 Inhibitors;Methods and Principles in Medicinal Chemistry;2013-11

4. An overview of Glyt-1 inhibitors under evaluation for the treatment of schizophrenia;Drugs of the Future;2013

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