The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck)-Reference-Cited by-同舟云学术

The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck)

Published:2006-12 Issue:23 Volume:16 Page:5973-5977
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Sabat Mark,VanRens John C.,Laufersweiler Matthew J.,Brugel Todd A.,Maier Jennifer,Golebiowski Adam,De Biswanath,Easwaran Vijayasurian,Hsieh Lily C.,Walter Richard L.,Mekel Marlene J.,Evdokimov Artem,Janusz Michael J.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference22 articles.

1. Profound block in thymocyte development in mice lacking p56lck

2. A dominant-negative transgene defines a role for p56lck in thymopoiesis.

3. Functional LCK Is Required for Optimal CD28-mediated Activation of the TEC Family Tyrosine Kinase EMT/ITK

4. LEUKOCYTE PROTEIN TYROSINE KINASES:Potential Targets for Drug Discovery

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