2,4-Diarylamino-pyrimidines as kinase inhibitors co-targeting IGF1R and EGFRL858R/T790M-Reference-Cited by-同舟云学术

2,4-Diarylamino-pyrimidines as kinase inhibitors co-targeting IGF1R and EGFRL858R/T790M

Published:2015-10 Issue:19 Volume:25 Page:4277-4281
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Chan Shingpan,Han Kun,Qu Rong,Tong Linjiang,Li Yingjun,Zhang Zhang,Cheng Huimin,Lu Xiaoyun,Patterson Adam,Smaill Jeff,Ren Xiaomei,Ding Jian,Xie Hua,Ding Ke

Funder

Ministry of Science and Technology of China

National Natural Science Foundation of China

National High Technology Research and Development (863) for Young Scientists program of China

Health Research Council of New Zealand

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference24 articles.

1. Gefitinib or Carboplatin–Paclitaxel in Pulmonary Adenocarcinoma

2. Screening for Epidermal Growth Factor Receptor Mutations in Lung Cancer

3. Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain

4. Second-generation irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs): A better mousetrap? A review of the clinical evidence

5. Discovery of a Mutant-Selective Covalent Inhibitor of EGFR that Overcomes T790M-Mediated Resistance in NSCLC

Cited by 21 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Diversification Via Coupling Reactions and Biological Activities of Pyrimidine Derivatives;ChemistrySelect;2023-12-15

2. Pyrimidine derivatives as EGFR tyrosine kinase inhibitors in non‐small‐cell lung cancer: A comprehensive review;Chemical Biology & Drug Design;2022-08-02

3. MicroRNAs as the critical regulators of tyrosine kinase inhibitors resistance in lung tumor cells;Cell Communication and Signaling;2022-03-09

4. Acid-controlled multicomponent selective synthesis of 2,4,6-triaryl pyridines and pyrimidines by using hexamethyldisilazane as a nitrogen source under microwave irradiation;RSC Advances;2022

5. Computational identification of 2,4-disubstituted amino-pyrimidines as L858R/T790M-EGFR double mutant inhibitors using pharmacophore mapping, molecular docking, binding free energy calculation, DFT study and molecular dynamic simulation;In Silico Pharmacology;2021-10-06