The discovery of 6-[2-(5-chloro-2-{[(2,4-difluorophenyl)methyl]oxy}phenyl)-1-cyclopenten-1-yl]-2-pyridinecarboxylic acid, GW848687X, a potent and selective prostaglandin EP1 receptor antagonist for the treatment of inflammatory pain-Reference-Cited by-同舟云学术

The discovery of 6-[2-(5-chloro-2-{[(2,4-difluorophenyl)methyl]oxy}phenyl)-1-cyclopenten-1-yl]-2-pyridinecarboxylic acid, GW848687X, a potent and selective prostaglandin EP1 receptor antagonist for the treatment of inflammatory pain

Published:2007-01 Issue:2 Volume:17 Page:385-389
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Giblin Gerard M.P.,Bit Rino A.,Brown Susan H.,Chaignot Hélène M.,Chowdhury Anita,Chessell Iain P.,Clayton Nicholas M.,Coleman Tanya,Hall Adrian,Hammond Beverley,Hurst David N.,Michel Anton D.,Naylor Alan,Novelli Riccardo,Scoccitti Tiziana,Spalding David,Tang Sac P.,Wilson Alex W.,Wilson Rich

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference36 articles.

1. Prostaglandin E synthase

2. Microsomal Prostaglandin E Synthase-1 Is a Major Terminal Synthase That Is Selectively Up-Regulated During Cyclooxygenase-2-Dependent Prostaglandin E2 Production in the Rat Adjuvant-Induced Arthritis Model

3. Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase

4. Reduced Pain Hypersensitivity and Inflammation in Mice Lacking Microsomal Prostaglandin E Synthase-1

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