10-Hydroxy-7,8-dihydropyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-diones: Potent, orally bioavailable HIV-1 integrase strand-transfer inhibitors with activity against integrase mutants-Reference-Cited by-同舟云学术

10-Hydroxy-7,8-dihydropyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-diones: Potent, orally bioavailable HIV-1 integrase strand-transfer inhibitors with activity against integrase mutants

Published:2008-08 Issue:16 Volume:18 Page:4581-4583
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Wiscount Catherine M.,Williams Peter D.,Tran Lekhanh O.,Embrey Mark W.,Fisher Thorsten E.,Sherman Vanessa,Homnick Carl F.,Donnette Staas D.,Lyle Terry A.,Wai John S.,Vacca Joseph P.,Wang ZiQiang,Felock Peter J.,Stillmock Kara A.,Witmer Marc V.,Miller Michael D.,Hazuda Daria J.,Day Alysha M.,Gabryelski Lori J.,Ecto Linda T.,Schleif William A.,DiStefano Daniel J.,Kochansky Christopher J.,Reza Anari M.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference11 articles.

1. HIV-1 Integrase: A Target for New AIDS Chemotherapeutics

2. HIV Integrase Inhibitors: From Diketoacids to Heterocyclic Templates: A History of HIV Integrase Medicinal Chemistry at Merck West Point and Merck Rome (IRBM)

3. 8-Hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors

4. Diketo acid inhibitor mechanism and HIV-1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes

5. Absolute configuration of 6-methyl-5,6,7,8-tetrahydropterin produced by enzymic reduction (dihydrofolate reductase and NADPH) of 6-methyl-7,8-dihydropterin

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