Structure-activity relationship study of small molecule inhibitors of the DEPTOR-mTOR interaction-Reference-Cited by-同舟云学术

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Structure-activity relationship study of small molecule inhibitors of the DEPTOR-mTOR interaction

Published:2017-10 Issue:20 Volume:27 Page:4714-4724
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Lee Jihye,Shi Yijiang,Vega Mario,Yang Yonghui,Gera Joseph,Jung Michael E.,Lichtenstein Alan

Funder

NIH

Veteran’s Administration

Multiple Myeloma Research Foundation

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference13 articles.

1. DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival;Peterson;Cell,2009

2. High resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients;Carrasco;Cancer Cell,2006

3. DEPTOR is linked to a TORC1-p21 survival proliferation pathway in multiple myeloma cells;Yang;Genes Cancer,2014

4. Cytotoxic properties of a DEPTOR-mTPR inhibitor in multiple myeloma cells;Shi;Cancer Res,2016

5. Cyclisch konjugierte 5- und 7-Ringsysteme I. 6-Amino- sowie 6-Hydroxy-fulvene und deren Aza-analoga;Hafner;Liebigs Ann Chem,1964

Cited by 11 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation;Journal of Biological Chemistry;2022-04

2. Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace;eLife;2021-09-14

3. Exploring novel and potent molecules for disrupting DEPTOR-mTOR interaction through structure-steered screening, extra-exactitude molecular docking, prime binding free energy estimation and voguish molecular dynamics;Journal of Biomolecular Structure and Dynamics;2021-08-25

4. Structural Basis of DEPTOR to Recognize Phosphatidic Acid Using its Tandem DEP Domains;Journal of Molecular Biology;2021-06

5. Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace;2021-04-30

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