Design and synthesis of novel and potent GPR119 agonists with a spirocyclic structure-Reference-Cited by-同舟云学术

Design and synthesis of novel and potent GPR119 agonists with a spirocyclic structure

Published:2018-04 Issue:7 Volume:28 Page:1228-1233
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Harada Kazuhito,Mizukami Jun,Kadowaki Sho,Matsuda Isamu,Watanabe Takashi,Oe Yasuhiro,Kodama Yoshitoshi,Aoki Kenta,Suwa Katsunori,Fukuda Sumiaki,Yata Shinji,Inaba Takashi

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference21 articles.

1. A Role for β-Cell-Expressed G Protein-Coupled Receptor 119 in Glycemic Control by Enhancing Glucose-Dependent Insulin Release

2. A Role for Intestinal Endocrine Cell-Expressed G Protein-Coupled Receptor 119 in Glycemic Control by Enhancing Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Peptide Release

3. G Protein-Coupled Receptor 119 (GPR119) Agonists for the Treatment of Diabetes: Recent Progress and Prevailing Challenges

4. GPR119 agonists as potential new oral agents for the treatment of type 2 diabetes and obesity

5. Design and synthesis of 1H-pyrazolo[3,4-c]pyridine derivatives as a novel structural class of potent GPR119 agonists

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