A katG S315T or an ahpC promoter mutation mediate Mycobacterium tuberculosis resistance to 2-thiophen carboxylic acid hydrazide, an inhibitor resembling the anti-tubercular drugs Isoniazid and Ethionamide

Author:

Franceschelli Jorgelina J.,Belardinelli Juan M.,Tong Ping,Loftus Brendan,Recio-Balsells Alejandro,Labadié Guillermo R.ORCID,Gordon Stephen V.,Morbidoni Hector R.

Funder

ANPCyT

Science Foundation Ireland

Publisher

Elsevier BV

Subject

Infectious Diseases,Microbiology (medical),Immunology,Microbiology

Reference45 articles.

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2. Evaluation of p-nitro benzoic acid (pnb) inhibition test to differentiate Mycobacterium tuberculosis complex from non-tuberculous mycobacteria using microscopic observation of drug susceptibility (MODS) methodology;Agarwal;Indian J Tubercul,2014

3. Molecular analysis of isoniazid-resistant Mycobacterium tuberculosis isolates from England and Wales reveals the phylogenetic significance of the ahpC -46A polymorphism;Baker;Antimicrob Agents Chemother,2005

4. Theoretical investigations on molecular structure, vibrational spectra, HOMO, LUMO, NBO analysis and hyperpolarizability calculations of thiophene-2-carbohydrazide;Balachandran;Spectrochim Acta A Mol Biomol Spectrosc,2014

5. inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis;Banerjee;Science,1994

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