VEGFR2-targeted antibody fused with IFN mut regulates the tumor microenvironment of colorectal cancer and exhibits potent anti-tumor and anti-metastasis activity

Author:

Shang Pengzhao,Gao Rui,Zhu Yijia,Zhang Xiaorui,Wang Yang,Guo Minji,Peng Hui,Wang Min,Zhang Juan

Funder

“Double First-Class” University Project

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

Postgraduate Research & Practice Innovation Program of Jiangsu Province

National Students’ Platform for Innovation and Entrepreneurship Training Program

Publisher

Elsevier BV

Subject

General Pharmacology, Toxicology and Pharmaceutics

Reference48 articles.

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3. Metronomic chemotherapy in metastatic colorectal cancer;Woo;Canc Lett,2017

4. Phase IB study of vemurafenib in combination with irinotecan and cetuximab in patients with metastatic colorectal cancer with BRAFV600E mutation;Hong;Canc Discov,2016

5. FDA approval summary: ramucirumab for gastric cancer;Casak;Clin Canc Res,2015

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