Novel phenyl-urea derivatives as dual-target ligands that can activate both GK and PPARγ-Reference-Cited by-同舟云学术

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Novel phenyl-urea derivatives as dual-target ligands that can activate both GK and PPARγ

Published:2012-12 Issue:6 Volume:2 Page:588-597
ISSN:2211-3835
Container-title:Acta Pharmaceutica Sinica B
language:en
Short-container-title:Acta Pharmaceutica Sinica B

Author:

Zhang Lijian,Tian Kang,Li Yongqiang,Lei Lei,Qin Aifang,Zhang Lijuan,Song Hongrui,Huo Lianchao,Zhang Lijing,Jin Xiaofeng,Shen Zhufang,Feng Zhiqiang

Funder

National S&T Major Special Project on Major New Drug Innovation

National Nature Science Foundation of China

Publisher

Elsevier BV

Subject

General Pharmacology, Toxicology and Pharmaceutics

Reference15 articles.

1. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030;Wild;Diabetes Care,2004

2. Insulin signalling and the regulation of glucose and lipid metabolism;Saltiel;Nature,2001

3. Berberine in type 2 diabetes therapy: a new perspective for an old antidiarrheal drug?;Zhang;Acta Pharm Sin B,2012

4. Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities;Matschinsky;Diabetes,1998

5. Allosteric activators of glucokinase: potential role in diabetes therapy;Grimsby;Science,2003

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1. Molecular docking, 2D-QSAR and ADMET studies of 4-sulfonyl-2-pyridone heterocycle as a potential glucokinase activator;Results in Chemistry;2023-12

2. Efficient Consecutive Synthesis of Ethyl-2-(4-Aminophenoxy) Acetate, a Precursor for Dual GK and PPARγ Activators, X-ray Structure, Hirshfeld Analysis, and DFT Studies;Crystals;2022-02-05

3. Recent Developments in Medicinal Chemistry of Allosteric Activators of Human Glucokinase for Type 2 Diabetes Mellitus Therapeutics;Current Pharmaceutical Design;2020-06-24

4. Synthesis of a 1,2,3-bistriazole derivative of embelin and evaluation of its effect on high-fat diet fed-streptozotocin-induced type 2 diabetes in rats and molecular docking studies;Bioorganic Chemistry;2020-03

5. Dual palladium–photoredox catalyzed chemoselective C–H arylation of phenylureas;Chemical Communications;2020

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