Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism: WLB-73502, an analgesic with improved efficacy and safety profile compared to strong opioids-Reference-Cited by-同舟云学术

Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism: WLB-73502, an analgesic with improved efficacy and safety profile compared to strong opioids

Published:2023-01 Issue:1 Volume:13 Page:82-99
ISSN:2211-3835
Container-title:Acta Pharmaceutica Sinica B
language:en
Short-container-title:Acta Pharmaceutica Sinica B

Author:

Vidal-Torres Alba^ORCID,Fernández-Pastor Begoña,García Mónica^ORCID,Ayet Eva^ORCID,Cabot Anna,Burgueño Javier^ORCID,Monroy Xavier,Aubel Bertrand,Codony Xavier,Romero Luz^ORCID,Pascual Rosalía,Serafini Maria Teresa^ORCID,Encina Gregorio^ORCID,Almansa Carmen^ORCID,Zamanillo Daniel^ORCID,Merlos Manuel^ORCID,Vela José Miguel^ORCID

Funder

Centro para el Desarrollo Tecnológico Industrial

Publisher

Elsevier BV

Subject

General Pharmacology, Toxicology and Pharmaceutics

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1. Endogenous opiates and behavior: 2023;Peptides;2024-09

2. Bispecific Sigma1R-Antagonist/MOR-Agonist Compounds for Pain;Cureus;2024-05-07

3. A Novel Bifunctional μOR Agonist and σ₁R Antagonist with Potent Analgesic Responses and Reduced Adverse Effects;Journal of Medicinal Chemistry;2023-11-28

4. IUPHAR Review - Bivalent and bifunctional opioid receptor ligands as novel analgesics;Pharmacological Research;2023-11