Structure‒tissue exposure/selectivity relationship (STR) correlates with clinical efficacy/safety
Author:
Funder
Celgene
Publisher
Elsevier BV
Subject
General Pharmacology, Toxicology and Pharmaceutics
Reference95 articles.
1. Trends in clinical success rates and therapeutic focus;Dowden;Nat Rev Drug Discov,2019
2. The current status of drug discovery and development as originated in United States academia: the influence of industrial and academic collaboration on drug discovery and development;Takebe;Clin Transl Sci,2018
3. Phase II and Phase III failures: 2013-2015;Harrison;Nat Rev Drug Discov,2016
4. Why 90% of clinical drug development fails and how to improve it;Sun;Acta Pharm Sin B,2022
5. Activity landscape representations for structure−activity relationship analysis;Wassermann;J Med Chem,2010
Cited by 10 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Conformation, virtual cocrystal screening, synthesis and determination of dipyridamole;Journal of Molecular Structure;2024-12
2. Characterization of active alkaloids and metabolites in rats after oral administration of Zuojin Pill using UHPLC-Q-TOF-MS combined with bioinformatics and molecular docking analyses;Journal of Pharmaceutical and Biomedical Analysis;2024-10
3. Can Machine Learning Overcome the 95% Failure Rate and Reality that Only 30% of Approved Cancer Drugs Meaningfully Extend Patient Survival?;Journal of Medicinal Chemistry;2024-09-10
4. In silico off-target profiling for enhanced drug safety assessment;Acta Pharmaceutica Sinica B;2024-07
5. Progress and application of lung-on-a-chip for lung cancer;Frontiers in Bioengineering and Biotechnology;2024-05-24
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3