A Comparison of Ten Polygenic Score Methods for Psychiatric Disorders Applied Across Multiple Cohorts

Author:

Ni Guiyan,Zeng JianORCID,Revez Joana A.ORCID,Wang Ying,Zheng Zhili,Ge Tian,Restuadi Restuadi,Kiewa Jacqueline,Nyholt Dale R.ORCID,Coleman Jonathan R.I.ORCID,Smoller Jordan W.ORCID,Yang JianORCID,Visscher Peter M.,Wray Naomi R.ORCID,Ripke Stephan,Neale Benjamin M.,Corvin Aiden,Walters James T.R.,Farh Kai-How,Holmans Peter A.,Lee Phil,Bulik-Sullivan Brendan,Collier David A.,Huang Hailiang,Pers Tune H.,Agartz Ingrid,Agerbo Esben,Albus Margot,Alexander Madeline,Amin Farooq,Bacanu Silviu A.,Begemann Martin,Belliveau Richard A.,Bene Judit,Bergen Sarah E.,Bevilacqua Elizabeth,Bigdeli Tim B.,Black Donald W.,Bruggeman Richard,Buccola Nancy G.,Buckner Randy L.,Byerley William,Cahn Wiepke,Cai Guiqing,Campion Dominique,Cantor Rita M.,Carr Vaughan J.,Carrera Noa,Catts Stanley V.,Chambert Kimberley D.,Chan Raymond C.K.,Chen Ronald Y.L.,Chen Eric Y.H.,Cheng Wei,Cheung Eric F.C.,Chong Siow Ann,Cloninger C. Robert,Cohen David,Cohen Nadine,Cormican Paul,Craddock Nick,Crowley James J.,Davidson Michael,Davis Kenneth L.,Degenhardt Franziska,Del Favero Jurgen,Demontis Ditte,Dikeos Dimitris,Dinan Timothy,Djurovic Srdjan,Donohoe Gary,Drapeau Elodie,Duan Jubao,Dudbridge Frank,Durmishi Naser,Eichhammer Peter,Eriksson Johan,Escott-Price Valentina,Essioux Laurent,Fanous Ayman H.,Farrell Martilias S.,Frank Josef,Franke Lude,Freedman Robert,Freimer Nelson B.,Friedl Marion,Friedman Joseph I.,Fromer Menachem,Genovese Giulio,Georgieva Lyudmila,Giegling Ina,Giusti-Rodríguez Paola,Godard Stephanie,Goldstein Jacqueline I.,Golimbet Vera,Gopal Srihari,Gratten Jacob,de Haan Lieuwe,Hammer Christian,Hamshere Marian L.,Hansen Mark,Hansen Thomas,Haroutunian Vahram,Hartmann Annette M.,Henskens Frans A.,Herms Stefan,Hirschhorn Joel N.,Hoffmann Per,Hofman Andrea,Hollegaard Mads V.,Hougaard David M.,Ikeda Masashi,Joa Inge,Julià Antonio,Kahn René S.,Kalaydjieva Luba,Karachanak-Yankova Sena,Karjalainen Juha,Kavanagh David,Keller Matthew C.,Kennedy James L.,Khrunin Andrey,Kim Yunjung,Klovins Janis,Knowles James A.,Konte Bettina,Kucinskas Vaidutis,Kucinskiene Zita Ausrele,Kuzelova-Ptackova Hana,Kähler Anna K.,Laurent Claudine,Lee Jimmy,Lee S. Hong,Legge Sophie E.,Lerer Bernard,Li Miaoxin,Li Tao,Liang Kung-Yee,Lieberman Jeffrey,Limborska Svetlana,Loughland Carmel M.,Lubinski Jan,Lönnqvist Jouko,Macek Milan,Magnusson Patrik K.E.,Maher Brion S.,Maier Wolfgang,Mallet Jacques,Marsal Sara,Mattheisen Manuel,Mattingsdal Morten,McCarley Robert W.,McDonald Colm,McIntosh Andrew M.,Meier Sandra,Meijer Carin J.,Melegh Bela,Melle Ingrid,Mesholam-Gately Raquelle I.,Metspalu Andres,Michie Patricia T.,Milani Lili,Milanova Vihra,Mokrab Younes,Morris Derek W.,Mors Ole,Murphy Kieran C.,Murray Robin M.,Myin-Germeys Inez,Müller-Myhsok Bertram,Nelis Mari,Nenadic Igor,Nertney Deborah A.,Nestadt Gerald,Nicodemus Kristin K.,Nikitina-Zake Liene,Nisenbaum Laura,Nordin Annelie,O’Callaghan Eadbhard,O’Dushlaine Colm,O’Neill F. Anthony,Oh Sang-Yun,Olincy Ann,Olsen Line,Van Os Jim,International Consortium Psychosis Endophenotypes,Pantelis Christos,Papadimitriou George N.,Papiol Sergi,Parkhomenko Elena,Pato Michele T.,Paunio Tiina,Pejovic-Milovancevic Milica,Perkins Diana O.,Pietiläinen Olli,Pimm Jonathan,Pocklington Andrew J.,Powell John,Price Alkes,Pulver Ann E.,Purcell Shaun M.,Quested Digby,Rasmussen Henrik B.,Reichenberg Abraham,Reimers Mark A.,Richards Alexander L.,Roffman Joshua L.,Roussos Panos,Ruderfer Douglas M.,Salomaa Veikko,Sanders Alan R.,Schall Ulrich,Schubert Christian R.,Schulze Thomas G.,Schwab Sibylle G.,Scolnick Edward M.,Scott Rodney J.,Seidman Larry J.,Shi Jianxin,Sigurdsson Engilbert,Silagadze Teimuraz,Silverman Jeremy M.,Sim Kang,Slominsky Petr,Smoller Jordan W.,So Hon-Cheong,Spencer Chris C.A.,Stahl Eli A.,Stefansson Hreinn,Steinberg Stacy,Stogmann Elisabeth,Straub Richard E.,Strengman Eric,Strohmaier Jana,Stroup T. Scott,Subramaniam Mythily,Suvisaari Jaana,Svrakic Dragan M.,Szatkiewicz Jin P.,Söderman Erik,Thirumalai Srinivas,Toncheva Draga,Tosato Sarah,Veijola Juha,Waddington John,Walsh Dermot,Wang Dai,Wang Qiang,Webb Bradley T.,Weiser Mark,Wildenauer Dieter B.,Williams Nigel M.,Williams Stephanie,Witt Stephanie H.,Wolen Aaron R.,Wong Emily H.M.,Wormley Brandon K.,Xi Hualin Simon,Zai Clement C.,Zheng Xuebin,Zimprich Fritz,Wray Naomi R.,Stefansson Kari,Visscher Peter M.,Case-Control Consortium Wellcome Trust,Adolfsson Rolf,Andreassen Ole A.,Blackwood Douglas H.R.,Bramon Elvira,Buxbaum Joseph D.,Børglum Anders D.,Cichon Sven,Darvasi Ariel,Domenici Enrico,Ehrenreich Hannelore,Esko Tõnu,Gejman Pablo V.,Gill Michael,Gurling Hugh,Hultman Christina M.,Iwata Nakao,Jablensky Assen V.,Jönsson Erik G.,Kendler Kenneth S.,Kirov George,Knight Jo,Lencz Todd,Levinson Douglas F.,Li Qingqin S.,Liu Jianjun,Malhotra Anil K.,McCarroll Steven A.,McQuillin Andrew,Moran Jennifer L.,Mortensen Preben B.,Mowry Bryan J.,Nöthen Markus M.,Ophoff Roel A.,Owen Michael J.,Palotie Aarno,Pato Carlos N.,Petryshen Tracey L.,Posthuma Danielle,Rietschel Marcella,Riley Brien P.,Rujescu Dan,Sham Pak C.,Sklar Pamela,St Clair David,Weinberger Daniel R.,Wendland Jens R.,Werge Thomas,Daly Mark J.,Sullivan Patrick F.,O’Donovan Michael C.,Wray Naomi R.,Ripke Stephan,Mattheisen Manuel,Trzaskowski Maciej,Byrne Enda M.,Abdellaoui Abdel,Adams Mark J.,Agerbo Esben,Air Tracy M.,Andlauer Till F.M.,Bacanu Silviu-Alin,Bækvad-Hansen Marie,Beekman Aartjan T.F.,Bigdeli Tim B.,Binder Elisabeth B.,Bryois Julien,Buttenschøn Henriette N.,Bybjerg-Grauholm Jonas,Cai Na,Castelao Enrique,Christensen Jane Hvarregaard,Clarke Toni-Kim,Coleman Jonathan R.I.,Colodro-Conde Lucía,Couvy-Duchesne Baptiste,Craddock Nick,Crawford Gregory E.,Davies Gail,Deary Ian J.,Degenhardt Franziska,Derks Eske M.,Direk Nese,Dolan Conor V.,Dunn Erin C.,Eley Thalia C.,Escott-Price Valentina,Hassan Kiadeh Farnush Farhadi,Finucane Hilary K.,Foo Jerome C.,Forstner Andreas J.,Frank Josef,Gaspar Héléna A.,Gill Michael,Goes Fernando S.,Gordon Scott D.,Grove Jakob,Hall Lynsey S.,Hansen Christine Søholm,Hansen Thomas F.,Herms Stefan,Hickie Ian B.,Hoffmann Per,Homuth Georg,Horn Carsten,Hottenga Jouke-Jan,Hougaard David M.,Howard David M.,Ising Marcus,Jansen Rick,Jones Ian,Jones Lisa A.,Jorgenson Eric,Knowles James A.,Kohane Isaac S.,Kraft Julia,Kretzschmar Warren W.,Kutalik Zoltán,Li Yihan,Lind Penelope A.,MacIntyre Donald J.,MacKinnon Dean F.,Maier Robert M.,Maier Wolfgang,Marchini Jonathan,Mbarek Hamdi,McGrath Patrick,McGuffin Peter,Medland Sarah E.,Mehta Divya,Middeldorp Christel M.,Mihailov Evelin,Milaneschi Yuri,Milani Lili,Mondimore Francis M.,Montgomery Grant W.,Mostafavi Sara,Mullins Niamh,Nauck Matthias,Ng Bernard,Nivard Michel G.,Nyholt Dale R.,O’Reilly Paul F.,Oskarsson Hogni,Owen Michael J.,Painter Jodie N.,Pedersen Carsten Bøcker,Pedersen Marianne Giørtz,Peterson Roseann E.,Peyrot Wouter J.,Pistis Giorgio,Posthuma Danielle,Quiroz Jorge A.,Qvist Per,Rice John P.,Riley Brien P.,Rivera Margarita,Mirza Saira Saeed,Schoevers Robert,Schulte Eva C.,Shen Ling,Shi Jianxin,Shyn Stanley I.,Sigurdsson Engilbert,Sinnamon Grant C.B.,Smit Johannes H.,Smith Daniel J.,Stefansson Hreinn,Steinberg Stacy,Streit Fabian,Strohmaier Jana,Tansey Katherine E.,Teismann Henning,Teumer Alexander,Thompson Wesley,Thomson Pippa A.,Thorgeirsson Thorgeir E.,Traylor Matthew,Treutlein Jens,Trubetskoy Vassily,Uitterlinden André G.,Umbricht Daniel,Van der Auwera Sandra,van Hemert Albert M.,Viktorin Alexander,Visscher Peter M.,Wang Yunpeng,Webb Bradley T.,Weinsheimer Shantel Marie,Wellmann Jürgen,Willemsen Gonneke,Witt Stephanie H.,Wu Yang,Xi Hualin S.,Yang Jian,Zhang Futao,Arolt Volker,Baune Bernhard T.,Berger Klaus,Boomsma Dorret I.,Cichon Sven,Dannlowski Udo,de Geus E.J.C.,DePaulo J. Raymond,Domenici Enrico,Domschke Katharina,Esko Tõnu,Grabe Hans J.,Hamilton Steven P.,Hayward Caroline,Heath Andrew C.,Kendler Kenneth S.,Kloiber Stefan,Lewis Glyn,Li Qingqin S.,Lucae Susanne,Madden Pamela A.F.,Magnusson Patrik K.,Martin Nicholas G.,McIntosh Andrew M.,Metspalu Andres,Mors Ole,Mortensen Preben Bo,Müller-Myhsok Bertram,Nordentoft Merete,Nöthen Markus M.,O’Donovan Michael C.,Paciga Sara A.,Pedersen Nancy L.

Funder

National Health and Medical Research Council

Publisher

Elsevier BV

Subject

Biological Psychiatry

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