Effects of interactions of hepatocyte nuclear factor 4α isoforms with coactivators and corepressors are promoter-specific
Author:
Publisher
Wiley
Subject
Cell Biology,Genetics,Molecular Biology,Biochemistry,Structural Biology,Biophysics
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1016/S0014-5793(03)00174-1/fullpdf
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1. Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily.
2. A distant upstream promoter of the HNF-4alpha gene connects the transcription factors involved in maturity-onset diabetes of the young
3. An alternative splice variant of the tissue specific transcription factor HNF4 predominates in undifferentiated murine cell types
4. Expression of HNF4α isoforms in mouse liver development is regulated by sequential promoter usage and constitutive 3′ end splicing
5. Competitive Cofactor Recruitment by Orphan Receptor Hepatocyte Nuclear Factor 4α1: Modulation by the F Domain
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