Pharmacokinetics of 2,5-diaziridinyl-3,6-bis(2-hydroxyethylamino)-1,4-benzoquinone (BZQ, NSC 224070) during a phase I clinical trial-Reference-Cited by-同舟云学术

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Pharmacokinetics of 2,5-diaziridinyl-3,6-bis(2-hydroxyethylamino)-1,4-benzoquinone (BZQ, NSC 224070) during a phase I clinical trial

Published:1990-02 Issue:2 Volume:26 Page:107-112
ISSN:0277-5379
Container-title:European Journal of Cancer and Clinical Oncology
language:en
Short-container-title:European Journal of Cancer and Clinical Oncology

Author:

Betteridge Richard F.,Bosanquet Andrew G.,Gilby Edward D.

Publisher

Elsevier BV

Subject

Oncology

Reference14 articles.

1. Potential central nervous system antitumor agents;Khan,1976

2. Potential CNS antitumor agents VI: Aziridinylbenzoquinones III;Driscoll;J Pharm Sci,1979

3. Diaziquone (AZQ);Bender;Invest New Drugs,1983

4. Free radicals in quinone containing antitumor agents;Gutierrez,1983

5. Mechanism for the reductive activation of diaziquone;Mossoba;J Pharm Sci,1985

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1. Diaziridinylbenzoquinones;Methods in Enzymology;2004

2. Development of a lyophilised RH1 formulation: a novel DT diaphorase activated alkylating agent;Journal of Pharmacy and Pharmacology;2002-04

3. Clinical applications of quinone-containing alkylating agents;Frontiers in Bioscience;2000

4. Evaluation of rodent-only toxicology for early clinical trials with novel cancer therapeutics;British Journal of Cancer;1999-10-15

5. The Role of NAD(P)H:Quinone Oxidoreductase in Quinone-Mediated p21 Induction in Human Colon Carcinoma Cells;Archives of Biochemistry and Biophysics;1997-10

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