Pharmacokinetics of Brequinar sodium (NSC 368390) in patients with solid tumors during a phase I study

Author:

Schwartsmann G.,van der Vijgh W.J.F.,van Hennik M.B.,Klein I.,Vermorken J.B.,Dodion P.,ten Bokkel Huinink W.W.,Joggi G.,Gall H.,Crespeigne N.,Simonetti G.,Winograd B.,Pinedo H.M.

Publisher

Elsevier BV

Subject

Oncology

Reference15 articles.

1. Activity of a novel 4-quinolinecarboxylic acid, NSC 368390 [6-fluoro-2-(2′-fluoro-1,1′-biphenyl-4-yl)-3-methyl-4-quinoline carboxylic acid sodium salt] against experimental tumors;Dexter;Cancer Res,1985

2. Mechanism of action of the novel anticancer agent 6-fluoro-2-(2′-fluoro-1,1′-biphenyl-4-yl)-3-methyl-4-quinolinecarboxylic acid sodium salt (NSC 368390): inhibition of de novo pyrimidine nucleotide biosynthesis;Chen;Cancer Res,1986

3. Application of a new preclinical drug screening system for cancer of the large bowel;Scheithauer;Cancer Chemother Pharmacol,1988

4. Inhibition of pyrimidine de novo synthesis by DUP 785 (NSC 368390);Peters;Invest New Drugs,1987

5. DUP 785 (NSC 368390): schedule-dependency of growth-inhibitory and antipyrimidine effects;Schwartsmann;Biochem Pharmacol,1988

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