Discovery of MK-0476, a potent and orally active leukotriene D4 receptor antagonist devoid of peroxisomal enxyme induction-Reference-Cited by-同舟云学术

Discovery of MK-0476, a potent and orally active leukotriene D4 receptor antagonist devoid of peroxisomal enxyme induction

Published:1995-02 Issue:3 Volume:5 Page:283-288
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Labelle M.,Belley M.,Gareau Y.,Gauthier J.Y.,Guay D.,Gordon R.,Grossman S.G.,Jones T.R.,Leblanc Y.,McAuliffe M.,McFarlane C.,Masson P.,Metters K.M.,Ouimet N.,Patrick D.H.,Piechuta H.,Rochette C.,Sawyer N.,Xiang Y.B.,Pickett C.B.,Ford-Hutchinson A.W.,Zamboni R.J.,Young R.N.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference27 articles.

1. 677 The therapeutic effects of MK-571, a potent and selective leukotriene (LT) D receptor antagonist, in patients with chronic asthma

2. Lung function improvement in asthma with a cysteinylleukotriene receptor antagonist

3. The discovery of a new structural class of potent orally active leukotriene D4 antagonists

4. The discovery of L-699,392, a novel potent and orally active leukotriene D4 receptor antagonist

5. Enantioselective induction of peroxisomal proliferation in CD-1 mice by leukotriene antagonists

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