Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol

Author:

Lange Leslie A.,Hu Youna,Zhang He,Xue Chenyi,Schmidt Ellen M.,Tang Zheng-Zheng,Bizon Chris,Lange Ethan M.,Smith Joshua D.,Turner Emily H.,Jun Goo,Kang Hyun Min,Peloso Gina,Auer Paul,Li Kuo-ping,Flannick Jason,Zhang Ji,Fuchsberger Christian,Gaulton Kyle,Lindgren Cecilia,Locke Adam,Manning Alisa,Sim Xueling,Rivas Manuel A.,Holmen Oddgeir L.,Gottesman Omri,Lu Yingchang,Ruderfer Douglas,Stahl Eli A.,Duan Qing,Li Yun,Durda Peter,Jiao Shuo,Isaacs Aaron,Hofman Albert,Bis Joshua C.,Correa Adolfo,Griswold Michael E.,Jakobsdottir Johanna,Smith Albert V.,Schreiner Pamela J.,Feitosa Mary F.,Zhang Qunyuan,Huffman Jennifer E.,Crosby Jacy,Wassel Christina L.,Do Ron,Franceschini Nora,Martin Lisa W.,Robinson Jennifer G.,Assimes Themistocles L.,Crosslin David R.,Rosenthal Elisabeth A.,Tsai Michael,Rieder Mark J.,Farlow Deborah N.,Folsom Aaron R.,Lumley Thomas,Fox Ervin R.,Carlson Christopher S.,Peters Ulrike,Jackson Rebecca D.,van Duijn Cornelia M.,Uitterlinden André G.,Levy Daniel,Rotter Jerome I.,Taylor Herman A.,Gudnason Vilmundur,Siscovick David S.,Fornage Myriam,Borecki Ingrid B.,Hayward Caroline,Rudan Igor,Chen Y. Eugene,Bottinger Erwin P.,Loos Ruth J.F.,Sætrom Pål,Hveem Kristian,Boehnke Michael,Groop Leif,McCarthy Mark,Meitinger Thomas,Ballantyne Christie M.,Gabriel Stacey B.,O’Donnell Christopher J.,Post Wendy S.,North Kari E.,Reiner Alexander P.,Boerwinkle Eric,Psaty Bruce M.,Altshuler David,Kathiresan Sekar,Lin Dan-Yu,Jarvik Gail P.,Cupples L. Adrienne,Kooperberg Charles,Wilson James G.,Nickerson Deborah A.,Abecasis Goncalo R.,Rich Stephen S.,Tracy Russell P.,Willer Cristen J.,Gabriel Stacey B.,Altshuler David M.,Abecasis Gonçalo R.,Allayee Hooman,Cresci Sharon,Daly Mark J.,de Bakker Paul I.W.,DePristo Mark A.,Do Ron,Donnelly Peter,Farlow Deborah N.,Fennell Tim,Garimella Kiran,Hazen Stanley L.,Hu Youna,Jordan Daniel M.,Jun Goo,Kathiresan Sekar,Kang Hyun Min,Kiezun Adam,Lettre Guillaume,Li Bingshan,Li Mingyao,Newton-Cheh Christopher H.,Padmanabhan Sandosh,Peloso Gina,Pulit Sara,Rader Daniel J.,Reich David,Reilly Muredach P.,Rivas Manuel A.,Schwartz Steve,Scott Laura,Siscovick David S.,Spertus John A.,Stitziel Nathaniel O.,Stoletzki Nina,Sunyaev Shamil R.,Voight Benjamin F.,Willer Cristen J.,Rich Stephen S.,Akylbekova Ermeg,Atwood Larry D.,Ballantyne Christie M.,Barbalic Maja,Barr R. Graham,Benjamin Emelia J.,Bis Joshua,Boerwinkle Eric,Bowden Donald W.,Brody Jennifer,Budoff Matthew,Burke Greg,Buxbaum Sarah,Carr Jeff,Chen Donna T.,Chen Ida Y.,Chen Wei-Min,Concannon Pat,Crosby Jacy,Cupples L. Adrienne,D’Agostino Ralph,DeStefano Anita L.,Dreisbach Albert,Dupuis Josée,Durda J. Peter,Ellis Jaclyn,Folsom Aaron R.,Fornage Myriam,Fox Caroline S.,Fox Ervin,Funari Vincent,Ganesh Santhi K.,Gardin Julius,Goff David,Gordon Ora,Grody Wayne,Gross Myron,Guo Xiuqing,Hall Ira M.,Heard-Costa Nancy L.,Heckbert Susan R.,Heintz Nicholas,Herrington David M.,Hickson DeMarc,Huang Jie,Hwang Shih-Jen,Jacobs David R.,Jenny Nancy S.,Johnson Andrew D.,Johnson Craig W.,Kawut Steven,Kronmal Richard,Kurz Raluca,Lange Ethan M.,Lange Leslie A.,Larson Martin G.,Lawson Mark,Lewis Cora E.,Levy Daniel,Li Dalin,Lin Honghuang,Liu Chunyu,Liu Jiankang,Liu Kiang,Liu Xiaoming,Liu Yongmei,Longstreth William T.,Loria Cay,Lumley Thomas,Lunetta Kathryn,Mackey Aaron J.,Mackey Rachel,Manichaikul Ani,Maxwell Taylor,McKnight Barbara,Meigs James B.,Morrison Alanna C.,Musani Solomon K.,Mychaleckyj Josyf C.,Nettleton Jennifer A.,North Kari,O’Donnell Christopher J.,O’Leary Daniel,Ong Frank,Palmas Walter,Pankow James S.,Pankratz Nathan D.,Paul Shom,Perez Marco,Person Sharina D.,Polak Joseph,Post Wendy S.,Psaty Bruce M.,Quinlan Aaron R.,Raffel Leslie J.,Ramachandran Vasan S.,Reiner Alexander P.,Rice Kenneth,Rotter Jerome I.,Sanders Jill P.,Schreiner Pamela,Seshadri Sudha,Shea Steve,Sidney Stephen,Silverstein Kevin,Smith Nicholas L.,Sotoodehnia Nona,Srinivasan Asoke,Taylor Herman A.,Taylor Kent,Thomas Fridtjof,Tracy Russell P.,Tsai Michael Y.,Volcik Kelly A.,Wassel Chrstina L.,Watson Karol,Wei Gina,White Wendy,Wiggins Kerri L.,Wilk Jemma B.,Williams O. Dale,Wilson Gregory,Wilson James G.,Wolf Phillip,Zakai Neil A.,Hardy John,Meschia James F.,Nalls Michael,Singleton Andrew,Worrall Brad,Bamshad Michael J.,Barnes Kathleen C.,Abdulhamid Ibrahim,Accurso Frank,Anbar Ran,Beaty Terri,Bigham Abigail,Black Phillip,Bleecker Eugene,Buckingham Kati,Cairns Anne Marie,Caplan Daniel,Chatfield Barbara,Chidekel Aaron,Cho Michael,Christiani David C.,Crapo James D.,Crouch Julia,Daley Denise,Dang Anthony,Dang Hong,De Paula Alicia,DeCelie-Germana Joan,Drumm Allen DozorMitch,Dyson Maynard,Emerson Julia,Emond Mary J.,Ferkol Thomas,Fink Robert,Foster Cassandra,Froh Deborah,Gao Li,Gershan William,Gibson Ronald L.,Godwin Elizabeth,Gondor Magdalen,Gutierrez Hector,Hansel Nadia N.,Hassoun Paul M.,Hiatt Peter,Hokanson John E.,Howenstine Michelle,Hummer Laura K.,Kanga Jamshed,Kim Yoonhee,Knowles Michael R.,Konstan Michael,Lahiri Thomas,Laird Nan,Lange Christoph,Lin Lin,Lin Xihong,Louie Tin L.,Lynch David,Make Barry,Martin Thomas R.,Mathai Steve C.,Mathias Rasika A.,McNamara John,McNamara Sharon,Meyers Deborah,Millard Susan,Mogayzel Peter,Moss Richard,Murray Tanda,Nielson Dennis,Noyes Blakeslee,O’Neal Wanda,Orenstein David,O’Sullivan Brian,Pace Rhonda,Pare Peter,Parker H. Worth,Passero Mary Ann,Perkett Elizabeth,Prestridge Adrienne,Rafaels Nicholas M.,Ramsey Bonnie,Regan Elizabeth,Ren Clement,Retsch-Bogart George,Rock Michael,Rosen Antony,Rosenfeld Margaret,Ruczinski Ingo,Sanford Andrew,Schaeffer David,Sell Cindy,Sheehan Daniel,Silverman Edwin K.,Sin Don,Spencer Terry,Stonebraker Jackie,Tabor Holly K.,Varlotta Laurie,Vergara Candelaria I.,Weiss Robert,Wigley Fred,Wise Robert A.,Wright Fred A.,Wurfel Mark M.,Zanni Robert,Zou Fei,Nickerson Deborah A.,Rieder Mark J.,Green Phil,Shendure Jay,Akey Joshua M.,Bustamante Carlos D.,Crosslin David R.,Eichler Evan E.,Fox P. Keolu,Fu Wenqing,Gordon Adam,Gravel Simon,Jarvik Gail P.,Johnsen Jill M.,Kan Mengyuan,Kenny Eimear E.,Kidd Jeffrey M.,Lara-Garduno Fremiet,Leal Suzanne M.,Liu Dajiang J.,McGee Sean,O’Connor Timothy D.,Paeper Bryan,Robertson Peggy D.,Smith Joshua D.,Staples Jeffrey C.,Tennessen Jacob A.,Turner Emily H.,Wang Gao,Yi Qian,Jackson Rebecca,Peters Ulrike,Carlson Christopher S.,Anderson Garnet,Anton-Culver Hoda,Assimes Themistocles L.,Auer Paul L.,Beresford Shirley,Bizon Chris,Black Henry,Brunner Robert,Brzyski Robert,Burwen Dale,Caan Bette,Carty Cara L.,Chlebowski Rowan,Cummings Steven,Curb J. David,Eaton Charles B.,Ford Leslie,Franceschini Nora,Fullerton Stephanie M.,Gass Margery,Geller Nancy,Heiss Gerardo,Howard Barbara V.,Hsu Li,Hutter Carolyn M.,Ioannidis John,Jiao Shuo,Johnson Karen C.,Kooperberg Charles,Kuller Lewis,LaCroix Andrea,Lakshminarayan Kamakshi,Lane Dorothy,Lasser Norman,LeBlanc Erin,Li Kuo-Ping,Limacher Marian,Lin Dan-Yu,Logsdon Benjamin A.,Ludlam Shari,Manson JoAnn E.,Margolis Karen,Martin Lisa,McGowan Joan,Monda Keri L.,Kotchen Jane Morley,Nathan Lauren,Ockene Judith,O’Sullivan Mary Jo,Phillips Lawrence S.,Prentice Ross L.,Robbins John,Robinson Jennifer G.,Rossouw Jacques E.,Sangi-Haghpeykar Haleh,Sarto Gloria E.,Shumaker Sally,Simon Michael S.,Stefanick Marcia L.,Stein Evan,Tang Hua,Taylor Kira C.,Thomson Cynthia A.,Thornton Timothy A.,Van Horn Linda,Vitolins Mara,Wactawski-Wende Jean,Wallace Robert,Wassertheil-Smoller Sylvia,Zeng Donglin,Applebaum-Bowden Deborah,Feolo Michael,Gan Weiniu,Paltoo Dina N.,Sholinsky Phyliss,Sturcke Anne

Publisher

Elsevier BV

Subject

Genetics(clinical),Genetics

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