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Managing differential performance of polygenic risk scores across groups: Real-world experience of the eMERGE Network

  • Published:2024-06 Issue:6 Volume:111 Page:999-1005
  • ISSN:0002-9297
  • Container-title:The American Journal of Human Genetics
  • language:en
  • Short-container-title:The American Journal of Human Genetics

Author:

Lewis Anna C.F.ORCID,Chisholm Rex L.,Connolly John J.,Esplin Edward D.,Glessner Joe,Gordon Adam,Green Robert C.,Hakonarson Hakon,Harr Margaret,Holm Ingrid A.,Jarvik Gail P.,Karlson Elizabeth,Kenny Eimear E.,Kottyan Leah,Lennon Niall,Linder Jodell E.,Luo Yuan,Martin Lisa J.,Perez Emma,Puckelwartz Megan J.,Rasmussen-Torvik Laura J.,Sabatello Maya,Sharp Richard R.,Smoller Jordan W.,Sterling Rene,Terek Shannon,Wei Wei-Qi,Fullerton Stephanie M.

Funder

Icahn School of Medicine at Mount Sinai

University of Washington

Columbia University

Cincinnati Children's Hospital Medical Center

Children's Hospital of Philadelphia

NHGRI

Biogen

Mayo Clinic

Vanderbilt University Medical Center

Northwestern University

National Center for Advancing Translational Sciences

Publisher

Elsevier BV

Reference26 articles.

1. Clinical use of current polygenic risk scores may exacerbate health disparities;Martin;Nat. Genet.,2019

2. Getting genetic ancestry right for science and society;Lewis;Science,2022

3. Facing Our History—Building an Equitable Future;Jackson;Am. J. Hum. Genet.,2023

4. Fatal Invention: How Science, Politics, and Big Business Re-create Race in the Twenty-First Century;Roberts,2011

5. Returning integrated genomic risk and clinical recommendations: The eMERGE study;Linder;Genet. Med.,2023

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