Structural prediction, whole exome sequencing and molecular dynamics simulation confirms p.G118D somatic mutation of PIK3CA as functionally important in breast cancer patients

Author:

Masoodi Tariq Ahmad,Shaik Noor Ahmad,Burhan Syed,Hasan Qurratulain,Shafi Gowhar,Talluri Venkateswara Rao

Publisher

Elsevier BV

Subject

Computational Mathematics,Organic Chemistry,Biochemistry,Structural Biology

Reference37 articles.

1. Comprehensive molecular portraits of human breast tumours;Cancer Genome Atlas N;Nature,2012

2. Human Splicing Finder: an online bioinformatics tool to predict splicing signals;Desmet;Nucleic Acids Res.,2009

3. Multicenter breast cancer collaborative registry;Sherman;Cancer Inform.,2011

4. Role of E542 and E545 missense mutations of PIK3CA in breast cancer: a comparative computational approach;Thirumal Kumar;J. Biomol. Struct. Dyn.,2016

5. Mutation of the PIK3CA oncogene in human cancers;Karakas;Br. J. Cancer,2006

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