The point mutation of the cholesterol trafficking membrane protein NPC1 may affect its proper function in more than a single step: Molecular dynamics simulation study-Reference-Cited by-同舟云学术

The point mutation of the cholesterol trafficking membrane protein NPC1 may affect its proper function in more than a single step: Molecular dynamics simulation study

Published:2022-08 Issue: Volume:99 Page:107725
ISSN:1476-9271
Container-title:Computational Biology and Chemistry
language:en
Short-container-title:Computational Biology and Chemistry

Author:

Yoon Hye-Jin,Jeong Jian,Kim Guun,Lee Hyung Ho,Jang Soonmin

Funder

National Research Foundation of Korea

National Supercomputing Center, Korea Institute of Science and Technology Information

Publisher

Elsevier BV

Subject

Computational Mathematics,Organic Chemistry,Biochemistry,Structural Biology

Reference46 articles.

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2. Evidence for a Niemann–Pick C (NPC) gene family: identification and characterization of NPC1L1;Davies;Genomics,2000

3. Niemann–Pick type C 1 function requires lumenal domain residues that mediate cholesterol-dependent NPC2 binding;Deffieu;Proc. Natl. Acad. Sci. USA,2011

4. Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann–Pick C1;Du;Biochem. J.,2015

5. Cholesterol binding to the sterol-sensing region of Niemann Pick C1 protein confines dynamics of its N-terminal domain;Dubey;PLoS Comput. Biol.,2020

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1. An overview of the role of Niemann-pick C1 (NPC1) in viral infections and inhibition of viral infections through NPC1 inhibitor;Cell Communication and Signaling;2023-12-14

2. Binding free energy of several sterols to the N‐terminal domain of Niemann‐Pick C1 ‐like 1 protein due to mutation: Molecular dynamics study;Journal of the Chinese Chemical Society;2022-10