GAP positions catalytic H-Ras residue Q61 for GTP hydrolysis in molecular dynamics simulations, complicating chemical rescue of Ras deactivation
Author:
Publisher
Elsevier BV
Subject
Computational Mathematics,Organic Chemistry,Biochemistry,Structural Biology
Reference97 articles.
1. GROMACS: high performance molecular simulations through multi-level parallelism from laptops to supercomputers;Abraham;SoftwareX,2015
2. Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain;Adari;Science,1988
3. KRAS prenylation is required for bivalent binding with calmodulin in a nucleotide-independent manner;Agamasu;Biophys. J.,2019
4. Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras;Ahmadian;Nat. Struct. Biol.,1997
5. Structural fingerprints of the Ras-GTPase activating proteins neurofibromin and p120GAP;Ahmadian;J. Mol. Biol.,2003
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