Cellular Activity in E-PTFE Reconstructed Pulleys and Adjacent Regions of Deep Flexor Tendons

Author:

HANFF G.1,ABRAHAMSSON S-O.1

Affiliation:

1. From the Department of Hand Surgery, University Hospital, Malmö, Sweden

Abstract

The biological adaption and integration of flexor tendon pulleys reconstructed with expanded polytetrafluorethylene (e-PTFE) were investigated 3 months after operation. E-PTFE pulleys showed no signs of failure, adverse tissue reactions or detrimental effects on the surface of underlying tendons. Cells in pulleys reconstructed with e-PTFE synthesized proteoglycan, collagen and non-collagen protein at a higher rate, and DNA at a lower rate, than cells in sham operated pulleys. Cells in pulleys reconstructed with e-PTFE synthesized proteoglycan at a lower rate, and protein at a higher rate, than cells in e-PTFE strips placed subcutaneously. Flexor tendon segments underlying reconstructed or sham operated pulleys synthesized matrix components and DNA at comparable rates.

Publisher

SAGE Publications

Subject

Transplantation,Surgery

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