Bretylium tosylate binds preferentially to muscarinic receptors labelled with [3H]oxotremorine M (SH or ‘high affinity’ receptors) in rat heart and brain cortex

Author:

Gillard Michel,Brunner Friedrich,Waelbroeck Magali,Svoboda Michal,Christophe Jean

Publisher

Elsevier BV

Subject

Pharmacology

Reference16 articles.

1. Pirenzepine - a ligand with original binding properties to muscarinic receptors;Birdsall;Scand. J. Gastroenterol.,1980

2. The effect of McN-A-343 on muscarinic receptors in the cerebral cortex and heart;Birdsall;Br. J. Pharmacol.,1983

3. Relationship between the inhibition constant (Ki) and the concentration of inhibitor which causes 50 per cent inhibition (IC50) of an enzymatic reaction;Cheng;Biochem. Pharmacol.,1973

4. Action of agonists and antagonists at muscarinic receptors present on ileum and atria in vitro;Clague;Br. J. Pharmacol.,1985

5. Muscarinic receptor heterogeneity in rat central nervous system. II. Brain receptors labeled by [3H]oxotremorine-M correspond to heterogenous M2 receptors with very high affinity for agonists;Gillard;Mol. Pharmacol.,1987

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