Direct measurement of muscarinic agents in the central nervous system of mice using ex vivo binding

Author:

Freedman S.B.,Harley E.A.,Patel S.

Publisher

Elsevier BV

Subject

Pharmacology

Reference17 articles.

1. ‘Ex vivo’ binding: A measure of drug penetration in the CNS;Carroll;Br. J. Pharmacol.,1987

2. Relationship between the inhibition constant (Ki) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction;Cheng;Biochem. Pharmacol.,1973

3. Antagonism of aceclidine-induced tremor, analgesia, hypothermia, salivation and lacrimation by some pharmacologic agents;Chiang;Arch. Int. Pharmacodyn.,1971

4. Quantitative ‘in vivo’ receptor binding I: Theory and application to the muscarinic cholinergic receptor;Frey;J. Neurosci.,1985

5. Relative affinities of drugs at cholinoceptors in displacing agonist and antagonist radioligands: the NMS/Oxo-M ratio as an index of efficacy at cortical muscarinic receptors;Freedman;Br. J. Pharmacol.,1988

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