The novel anticonvulsant MK-801 interacts with central phencyclidine recognition sites in rat brain

Author:

Loo Patricia A.,Braunwalder Albert F.,Williams Michael,Sills Matthew A.

Publisher

Elsevier BV

Subject

Pharmacology

Reference5 articles.

1. The dissociative anesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurons by N-methyl-aspartate;Anis;Br. J. Pharmacol.,1983

2. Restoration of shock suppressed behavior by treatment with (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10-imine (MK 801), a substance with potent anticonvulsant, central sympathomimetic and apparent anxiolytic properties;Clineschmidt;Drug Dev. Res.,1982

3. Radioligand binding to central phencyclidine recognition sites is dependent on excitatory amino acid receptor agonists;Loo;European J. Pharmacol.,1986

4. Murphy, D.E., J. Schneider, C. Boehm, J. Lehmann and M. Williams, Binding of [3H]CPP (3-(2-carboxypiperazine-4-yl)propyl-1-phosphonic acid) to rat brain membranes: a selective, high affinity ligand for N-methyl-D-aspartate (NMDA) receptors, J. Pharmacol. Exp. Ther. (in press).

5. The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist;Wong,1986

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