Metabolites of haloperidol display preferential activity at σ receptors compared to dopamine D-2 receptors

Author:

Bowen Wayne D.,Moses Eydie L.,Tolentino Paul J.,Michael Walker J.

Publisher

Elsevier BV

Subject

Pharmacology

Reference30 articles.

1. The binding of agonists to brain muscarinic receptors;Birdsall;Mol. Pharmacol.,1978

2. Evidence for a multi-site model of the rat brain σ receptor;Bowen;European J. Pharmacol.,1989

3. σ Receptors negatively modulate agonist-stimulated phosphoinositide metabolism in rat brain;Bowen;European J. Pharmacol.,1988

4. Bowen, W.D., P.J. Tolentino, B.N. Kirschner, B.R. De Costa and K.C. Rice, Sigma receptors and signal transduction: Negative modulation of signalling through phosphoinositide-linked receptor systems, in: Sigma, PCP, and NMDA Receptor Systems - National Institute on Drug Abuse Research Monograph Series, eds. E.B. De Souza, E.D. London and D.H. Clouet (U.S. Government Printing Office, Washington, DC) (in press).

5. Bowen, W.D., P. Tolentino and P. Varghese, Investigation of the mechanism by which sigma ligands inhibit stimulation of phosphoinositide metabolism by muscarinic cholinergic agonists, in: Progress in Clinical and Biochemical Research, Volume 328: The International Narcotics Research Conference (INCR) '89, eds. R. Quirion, K. Jhamandas and C. Gianoulakis (Alan R. Liss, Inc., New York, NY) p. 81.

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