Double-edged roles of protein tyrosine phosphatase SHP2 in cancer and its inhibitors in clinical trials
Author:
Funder
National Natural Science Foundation of China
Publisher
Elsevier BV
Subject
Pharmacology (medical),Pharmacology
Reference150 articles.
1. Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop;Aceto;Nature Medicine,2012
2. Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signaling;Agazie;Molecular and Cellular Biology,2003
3. SHP-2 regulates SOCS-1-mediated Janus kinase-2 ubiquitination/degradation downstream of the prolactin receptor;Ali;Journal of Biological Chemistry,2003
4. The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy;Ardito;International Journal of Molecular Medicine,2017
5. Live-cell imaging of endogenous Ras-GTP illustrates predominant Ras activation at the plasma membrane;Augsten;EMBO Reports,2006
Cited by 71 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. The efficacy and safety of PI3K and AKT inhibitors for patients with cancer: A systematic review and network meta-analysis;European Journal of Pharmacology;2024-11
2. Targeting undruggable phosphatase overcomes trastuzumab resistance by inhibiting multi-oncogenic kinases;Drug Resistance Updates;2024-09
3. Advances in SHP2 tunnel allosteric inhibitors and bifunctional molecules;European Journal of Medicinal Chemistry;2024-09
4. Non-Receptor Tyrosine Kinases: Their Structure and Mechanistic Role in Tumor Progression and Resistance;Cancers;2024-08-02
5. Discovery of TK-642 as a highly potent, selective, orally bioavailable pyrazolopyrazine-based allosteric SHP2 inhibitor;Acta Pharmaceutica Sinica B;2024-08
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3