A review of bispecific antibodies and antibody constructs in oncology and clinical challenges

Author:

Suurs Frans V.,Lub-de Hooge Marjolijn N.,de Vries Elisabeth G.E.,de Groot Derk Jan A.

Publisher

Elsevier BV

Subject

Pharmacology (medical),Pharmacology

Reference172 articles.

1. First-in-human phase 1/2 study of MCLA-128, a full length IgG1 bispecific antibody targeting HER2 and HER3: Final phase 1 data and preliminary activity in HER2+ metastatic breast cancer (MBC);Alsina;Journal of Clinical Oncology,2017

2. Pretargeted imaging and therapy;Altai;Journal of Nuclear Medicine,2017

3. Therapeutic window of an EpCAM/CD3-specific BiTE antibody in mice is determined by a subpopulation of EpCAM-expressing lymphocytes that is absent in humans;Amann;Cancer Immunology, Immunotherapy,2009

4. Novel carcinoembryonic antigen T-cell bispecific (CEA-TCB) antibody: Preliminary clinical data as a single agent and in combination with atezolizumab in patients with metastatic colorectal cancer (mCRC);Argilés;Annals of Oncology,2017

5. Costimulation improves the killing capability of T cells redirected to tumor cells expressing low levels of CD33: Description of a novel modular targeting system;Arndt;Leukemia,2014

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