Methylene blue alleviates experimental autoimmune encephalomyelitis by modulating AMPK/SIRT1 signaling pathway and Th17/Treg immune response

Author:

Wang Jueqiong,Zhao Congying,Kong Peng,Bian Guanyun,Sun Zhe,Sun Yafei,Guo Li,Li Bin

Funder

National Natural Science Foundation of China

Publisher

Elsevier BV

Subject

Clinical Neurology,Neurology,Immunology,Immunology and Allergy

Reference55 articles.

1. IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice;Bettelli;J. Immunol.,1998

2. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity;Cantó;Nature,2009

3. Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB;Chen;EMBO J.,2002

4. Anti-IL-23 therapy inhibitsmultiple inflammatory pathways and ameliorates autoimmune encephalomyelitis;Chen;J. Clin. Invest.,2006

5. Origins of the T(H)1–T(H)2 model: a personal perspective;Coffman;Nat. Immunol.,2006

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