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In situ PEGylation of recombinant hirudin on an anion exchange chromatography column

  • Published:2017-04 Issue: Volume:55 Page:162-171
  • ISSN:1359-5113
  • Container-title:Process Biochemistry
  • language:en
  • Short-container-title:Process Biochemistry

Author:

Wang Xudong,Li Xueqin,Zhao Jun,Lv Li,Qin Kairong,Yuan Hengli,Xiu Zhilong

Funder

National Natural Science Foundation of China

Jiangsu Province State Key Laboratory Cultivating Base for Long-acting Bio-medical Research

Publisher

Elsevier BV

Subject

Applied Microbiology and Biotechnology,Biochemistry,Bioengineering

Reference35 articles.

1. The direct thrombin inhibitor hirudin;Greinacher;Thromb. Haemost.,2008

2. Treatment of heparin-induced thrombocytopenia;Dager;Ann. Pharmacother.,2002

3. Bivalent direct thrombin inhibitors: hirudin and bivalirudin;Warkentin;Best Pract. Res. Clin. Haematol.,2004

4. Process for protein PEGylation;Pfister;J. Controll. Release,2014

5. Biochemical and pharmacokinetic characterisation of two PEGylated variants of dipetarudin;Lopez;Thromb. Haemost.,2009

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