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TGF-β1 attenuates mitochondrial bioenergetics in pulmonary arterial endothelial cells via the disruption of carnitine homeostasis

  • Published:2020-09 Issue: Volume:36 Page:101593
  • ISSN:2213-2317
  • Container-title:Redox Biology
  • language:en
  • Short-container-title:Redox Biology

Author:

Sun Xutong,Lu Qing,Yegambaram Manivannan,Kumar Sanjiv,Qu Ning,Srivastava Anup,Wang Ting,Fineman Jeffrey R.,Black Stephen M.

Funder

National Heart, Lung, and Blood Institute

Publisher

Elsevier BV

Subject

Organic Chemistry,Biochemistry,Clinical Biochemistry

Reference97 articles.

1. Transforming growth factor-beta: master regulator of the respiratory system in Health and disease;Aschner;Am. J. Respir. Cell Mol. Biol.,2016

2. Transforming growth factor-betas and vascular disorders;Bobik;Arterioscler. Thromb. Vasc. Biol.,2006

3. TGF-beta and BMPR2 signaling in PAH: two black sheep in one family;Rol;Int. J. Mol. Sci.,2018

4. Vascular remodeling in primary pulmonary hypertension. Potential role for transforming growth factor-beta;Botney;Am. J. Pathol.,1994

5. Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease;Ma;J. Clin. Invest.,2011
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