A novel compound DBZ ameliorates neuroinflammation in LPS-stimulated microglia and ischemic stroke rats: Role of Akt(Ser473)/GSK3β(Ser9)-mediated Nrf2 activation

Author:

Liao Sha,Wu Jingni,Liu Ruimin,Wang Shixiang,Luo Jing,Yang YangORCID,Qin Yannan,Li Tao,Zheng Xiaopu,Song Jing,Zhao Xinfeng,Xiao Chaoni,Zhang Yajun,Bian Liujiao,Jia Pu,Bai Yajun,Zheng Xiaohui

Funder

LPS

Primary R&D Plan of Shaanxi Province

Scientific Research Plan Projects of Shaanxi Provincial Education Department

Project of Key Research and Development Plan of Shaanxi

Changjiang Scholars and Innovative Research Team in University

National Natural Science Foundation of China

Opening Foundation of Key Laboratory of Resource Biology and Biotechnology in Western China

Northwest University

Ministry of Education

Publisher

Elsevier BV

Subject

Organic Chemistry,Biochemistry,Clinical Biochemistry

Reference84 articles.

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2. Dissecting functional phenotypes of microglia and macrophages in the rat brain after transient cerebral ischemia;Rajan;Glia,2019

3. Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism;Block;Prog. Neurobiol.,2005

4. Microglia: active sensor and versatile effector cells in the normal and pathologic brain;Hanisch;Nat. Neurosci.,2007

5. Sublime microglia: expanding roles for the guardians of the CNS;Salter;Cell,2014

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