Genetic disruption of NRF2 promotes the development of necroinflammation and liver fibrosis in a mouse model of HFE-hereditary hemochromatosis

Author:

Duarte Tiago L.,Caldas Carolina,Santos Ana G.,Silva-Gomes Sandro,Santos-Gonçalves Andreia,Martins Maria João,Porto Graça,Lopes José Manuel

Funder

National funds through Fundação para a Ciência e a Tecnologia/Ministério da Educação e Ciência

COMPETE – Operational Competitiveness Programme

Norte Portugal Regional Operational Programme

European Regional Development Fund

Reitoria da Universidade do Porto/Santander

Publisher

Elsevier BV

Subject

Organic Chemistry,Biochemistry,Clinical Biochemistry

Reference48 articles.

1. Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment;Pietrangelo;Gastroenterology,2010

2. Mechanisms of iron hepatotoxicity;Pietrangelo;J. Hepatol.,2016

3. Modifying factors of the HFE hemochromatosis phenotype;Deugnier;Expert Rev. Gastroenterol. Hepatol.,2008

4. Haemochromatosis;Powell;Lancet,2016

5. Steatosis is a cofactor in liver injury in hemochromatosis;Powell;Gastroenterology,2005

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