Probing the β-pocket of the active site of human liver glycogen phosphorylase with 3-(C-β-d-glucopyranosyl)-5-(4-substituted-phenyl)-1, 2, 4-triazole inhibitors

Author:

Kyriakis Efthimios,Solovou Theodora G.A.,Kun Sándor,Czifrák Katalin,Szőcs Béla,Juhász László,Bokor Éva,Stravodimos George A.,Kantsadi Anastassia L.,Chatzileontiadou Demetra S.M.,Skamnaki Vassiliki T.,Somsák László,Leonidas Demetres D.

Funder

Biotechnology-Quality assessment in Nutrition and the Environment

Application of Molecular Biology-Molecular Genetics-Molecular Markers

Department of Biochemistry and Biotechnology

University of Thessaly

EU FP7 Programme

BioStruct-X

Hellenic State Scholarships Foundation

Support of human research resources through doctoral research

Operational Programme Education and Lifelong Learning

European Social Fund

National Resources

European Regional Development Fund

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference46 articles.

1. Natural products and their derivatives as inhibitors of glycogen phosphorylase: potential treatment for type 2 diabetes;Hayes;Phytochem. Rev.,2014

2. International, Diabetes, Federation, IDF Diabetes Atlas, Seventh Edition, Brussels, Belgium, 2015.

3. Biguanides and NIDDM;Bailey;Diabetes Care,1992

4. Type 2 diabetes-a matter of beta-cell life and death?;Rhodes;Science,2005

5. Effect of glucopyranosylidene-spiro-thiohydantoin on glycogen metabolism in liver tissues of streptozotocin-induced and obese diabetic rats;Docsa;Mol. Med. Report.,2011

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