4-Flourophenyl-substituted 5H-indeno[1,2-b]pyridinols with enhanced topoisomerase IIα inhibitory activity: Synthesis, biological evaluation, and structure–activity relationships

Author:

Kunwar Surendra,Hwang Soo-Yeon,Katila Pramila,Seo Minjung,Man Kadayat Tara,Kwon Youngjoo,Lee Eung-Seok

Funder

Ministry of Science and ICT, South Korea

National Research Foundation of Korea

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference32 articles.

1. Substituted 4, 5′-Bithiazoles as Catalytic Inhibitors of Human DNA Topoisomerase IIα;Bergant Loboda;J. Chem. Inf. Model.,2020

2. National Cancer Institute,USA. Cancer statistics. https://www.cancer.gov/about-cancer/understanding/statistics (accessed 28 April 2021).

3. Hallmarks of cancer: the next generation;Hanahan;Cell,2011

4. Cellular roles of DNA topoisomerases: a molecular perspective;Wang;Nat. Rev. Mol. Cell. Biol.,2002

5. Origin and evolution of DNA topoisomerases;Forterre;Biochimie,2007

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