Development of isatin-thiazolo[3,2-a]benzimidazole hybrids as novel CDK2 inhibitors with potent in vitro apoptotic anti-proliferative activity: Synthesis, biological and molecular dynamics investigations-Reference-Cited by-同舟云学术

Development of isatin-thiazolo[3,2-a]benzimidazole hybrids as novel CDK2 inhibitors with potent in vitro apoptotic anti-proliferative activity: Synthesis, biological and molecular dynamics investigations

Published:2021-05 Issue: Volume:110 Page:104748
ISSN:0045-2068
Container-title:Bioorganic Chemistry
language:en
Short-container-title:Bioorganic Chemistry

Author:

Eldehna Wagdy M.,El Hassab Mahmoud A.,Abo-Ashour Mahmoud F.,Al-Warhi Tarfah,Elaasser Mahmoud M.,Safwat Nesreen A.,Suliman Howayda,Ahmed Marwa F.,Al-Rashood Sara T.,Abdel-Aziz Hatem A.,El-Haggar Radwan

Funder

King Saud University

Princess Nourah bint Abdulrahman University

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference83 articles.

1. Cancer statistics, 2016;Siegel;CA Cancer J. Clin.,2016

2. Cancer statistics, 2020;Siegel;CA Cancer J. Clin.,2020

3. DNA-damaging agents in cancer chemotherapy: serendipity and chemical biology;Cheung-Ong;Chem. Biol.,2013

4. Direct demonstration in synthetic oligonucleotides that N, N'-bis(2-chloroethyl)-nitrosourea cross links N1 of deoxyguanosine to N3 of deoxycytidine on opposite strands of duplex DNA;Fischhaber;Cancer Res.,1999

5. Nitrogen mustard therapy; use of methyl-bis (beta-chloroethyl) amine hydrochloride and tris (beta-chloroethyl) amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders;Goodman;J. Am. Med. Assoc.,1946

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