Design, synthesis and biological evaluation of 2,3-dihydroimidazo[2,1-b]thiazoles as dual EGFR and IGF1R inhibitors

Author:

Gadekar Pradip K.,Urunkar Ganesh,Roychowdhury Abhijit,Sharma Rajiv,Bose Julie,Khanna Smriti,Damre Anagha,Sarveswari S.

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

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3. Acquired resistance to EGFR tyrosine kinase inhibitors incancer cells is mediated by loss of IGF-binding proteins;Guix;J. Clin Invest.,2008

4. Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of survivin expression counteract the antitumor action of erlotinib;Morgillo;Cancer. Res.,2006

5. Expression of epidermal growth factor receptor in human cultured cells and tissues: relationship to cell lineage and stage of differentiation;Real;Cancer Res.,1986

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