Design, synthesis, and biological evaluation of hydroxamic acid-substituted 2,4-diaryl aminopyrimidines as potent EGFRT790M/L858R inhibitors for the treatment of NSCLC-Reference-Cited by-同舟云学术

Design, synthesis, and biological evaluation of hydroxamic acid-substituted 2,4-diaryl aminopyrimidines as potent EGFRT790M/L858R inhibitors for the treatment of NSCLC

Published:2021-09 Issue: Volume:114 Page:105045
ISSN:0045-2068
Container-title:Bioorganic Chemistry
language:en
Short-container-title:Bioorganic Chemistry

Author:

Chen Lixue,Zhang Yunhao,Wang Changyuan,Tang Zeyao,Meng Qiang,Sun Hunjun,Qi Yan,Ma Xiaodong,Li Lei,Li Yanxia,Xu Youjun

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference28 articles.

1. Resisting Resistance: Targeted Therapies in Lung Cancer;Lin;Trends Cancer,2016

2. Cell and Molecular Biology of Epidermal Growth Factor Receptor;Ceresa;Int. Rev. Cel. Mol. Bio,2014

3. The ERBB network: at last, cancer therapy meets systems biology;Yarden;Nat. Rev. Cancer,2012

4. Investigating novel resistance mechanisms to third-generation EGFR tyrosine kinase inhibitor osimertinib in non-small cell lung cancer patients;Yang;Clin. Cancer Res.,2018

5. EGFR mutation prevalence in Asia-Pacific and Russian patients with advanced NSCLC of adenocarcinoma and nonadenocarcinoma histology: the IGNITE study;Han;Lung Cancer,2017

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Rational design and synthesis of 2,4‐dichloro‐6‐methyl pyrimidine derivatives as potential selective EGFR^T790M/L858R inhibitors for the treatment of non‐small cell lung cancer;Archiv der Pharmazie;2024-02-21

2. Triple targeting of mutant EGFR ^L858R/T790M , COX-2, and 15-LOX: design and synthesis of novel quinazolinone tethered phenyl urea derivatives for anti-inflammatory and anticancer evaluation;Journal of Enzyme Inhibition and Medicinal Chemistry;2023-04-11

3. Design, synthesis, and biological evaluation of 2-arylamino-4-(piperidin-4-yloxy)pyrimidines as potent EGFRT790M/L858R inhibitors to treat non-small cell lung cancer;Bioorganic & Medicinal Chemistry;2022-11

4. An Overview of the Biological Evaluation of Selected Nitrogen-Containing Heterocycle Medicinal Chemistry Compounds;International Journal of Molecular Sciences;2022-07-23

5. Synthesis and HDAC inhibitory activity of pyrimidine-based hydroxamic acids;Beilstein Journal of Organic Chemistry;2022-07-13