Design and synthesis of novel pyrazolo[3,4-d]pyrimidin-4-one bearing quinoline scaffold as potent dual PDE5 inhibitors and apoptotic inducers for cancer therapy-Reference-Cited by-同舟云学术

Design and synthesis of novel pyrazolo[3,4-d]pyrimidin-4-one bearing quinoline scaffold as potent dual PDE5 inhibitors and apoptotic inducers for cancer therapy

Published:2020-12 Issue: Volume:105 Page:104352
ISSN:0045-2068
Container-title:Bioorganic Chemistry
language:en
Short-container-title:Bioorganic Chemistry

Author:

Ibrahim Tarek S.,Hawwas Mohamed M.,Taher Ehab S.,Alhakamy Nabil A.,Alfaleh Mohamed A.,Elagawany Mohamed,Elgendy Bahaa,Zayed Gamal M.,Mohamed Mamdouh F.A.,Abdel-Samii Zakaria K.,Elshaier Yaseen A.M.M.

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference100 articles.

1. Targeting multiple kinase pathways: a change in paradigm;Gossage;Clin. Cancer Res.,2010

2. Introduction to cancer chemotherapeutics;Shewach;Chem. Rev.,2009

3. Design and synthesis of new quinoxaline derivatives as anticancer agents and apoptotic inducers;El Newahie;Molecules,2019

4. Synthesis, cytotoxic activity, and tubulin polymerization inhibitory activity of new pyrrol-2(3H)-ones and pyridazin-3(2H)-ones;Abdelbaset;Bioorg. Chem.,2018

5. Targeting tumour-supportive cellular machineries in anticancer drug development;Dobbelstein;Nat. Rev. Drug Discov.,2014

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