Pyridylethanol(phenylethyl)amines are non-azole, highly selective Candida albicans sterol 14α-demethylase inhibitors-Reference-Cited by-同舟云学术

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Pyridylethanol(phenylethyl)amines are non-azole, highly selective Candida albicans sterol 14α-demethylase inhibitors

Published:2021-01 Issue: Volume:106 Page:104472
ISSN:0045-2068
Container-title:Bioorganic Chemistry
language:en
Short-container-title:Bioorganic Chemistry

Author:

Ogris Iza,Zelenko Urška,Sosič Izidor,Gobec Martina,Skubic Cene,Ivanov Marija,Soković Marina,Kocjan Darko,Rozman Damjana,Golič Grdadolnik Simona

Funder

Ministry of Education, Science and Technological Development

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference48 articles.

1. Sterol 14α-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms;Lepesheva;BBA,2007

2. Structural basis for conservation in the CYP51 family;Lepesheva;BBA,1814

3. Sterol 14α-demethylase, an abundant and essential mixed-function oxidase;Waterman;Biochem. Biophys. Res. Commun.,2005

4. Lessons from hepatocyte-specific CYP51 knockout mice: impaired cholesterol synthesis leads to oval cell-driven liver injury;Lorbek;Sci. Rep.,2015

5. Disrupting hepatocyte CYP51 from cholesterol synthesis leads to progressive liver injury in the developing mouse and decreases RORC signalling;Urlep;Sci. Rep.,2017

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3. The expression pattern, subcellular localization and function of three sterol 14α-demethylases in Aspergillus oryzae;Frontiers in Genetics;2023-01-23

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5. In silico study and biological screening of benzoquinazolines as potential antimicrobial agents against methicillin-resistant Staphylococcus aureus, carbapenem-resistant Klebsiella pneumoniae, and fluconazole-resistant Candida albicans;Microbial Pathogenesis;2021-11

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