Synthesis and antitumor activity of α,β-unsaturated carbonyl moiety- containing oleanolic acid derivatives targeting PI3K/AKT/mTOR signaling pathway-Reference-Cited by-同舟云学术

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Synthesis and antitumor activity of α,β-unsaturated carbonyl moiety- containing oleanolic acid derivatives targeting PI3K/AKT/mTOR signaling pathway

Published:2020-08 Issue: Volume:101 Page:104036
ISSN:0045-2068
Container-title:Bioorganic Chemistry
language:en
Short-container-title:Bioorganic Chemistry

Author:

Wang Shi-Sheng,Zhang Qiao-Li,Chu Peng,Kong Ling-Qi,Li Guang-Zhe,Li Yue-Qing,Yang Li,Zhao Wei-Jie,Guo Xiu-Han,Tang Ze-Yao

Funder

National Natural Science Foundation of China

Natural Science Foundation of Liaoning Province

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference37 articles.

1. Oleanolic acid;Pollier;Phytochemistry,2012

2. Oeanolic acid protects against the hepatotoxicity of D-galactosame plus endotoxin in mice;Wan;Biomed. Pharmacother.,2017

3. Oleanolic acid reprograms the liver to protect against hepatotoxicants, but is hepatotoxic at high doses;Liu;Liver Int.,2019

4. Oleanane derivatives for pharmaceutical use: a patent review (2000–2016);Masullo;Expert Opin. Ther. Pat.,2017

5. Oleanolic acid and its synthetic derivatives for the prevention and therapy of cancer: Preclinical and clinical evidence;Shanmugam;Cancer Lett.,2014

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